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I have a pioneer 4100 and love it. Many people like the different menu systems of different brands and the different ipod integrations. Do some research and find what suits you best. For me it was a quality 7" double din with good reviews and excellent brand reputation.
This is a very personal matter for most people... It depends on how deep your pockets are... All the major brands are great... My choice is the Alpine IVA-W505. It's the heart of my system...