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Do you mean the whole axle assembly? If that is the case all you need do is lift the truck and support it, remove the old axle and install the new one. I would also change the diff fluid in the new one.
If you have plans to exchange a rear end and you don't know the steps, I would find some friends or family with more experience to help you out. You can keep things safe, end up with a proper installation, and bond with the guys.