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I'd say take them all in 1 trip. My one friend has a little old mazda pick up that he put 20-30 bags of coal into. He said it handled it. I would think you're fullsize should be fine.
I would just watch the rear suspension while you're loading. If you're about halfway loaded and the suspension is roughly halfway down then I would opt for 2 trips.
You don't get extra brownie points for doing it in one trip and damaging your truck.