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I drive a new FX4 with the 5.4. I went from stock 275-55 20s to 35X12.50 20s. I really didn't notice any lose. it might be the new engine.Even my buddy who is really very detailed was surprised.
Its usually 10lbs or a few less extra weight per wheel, and obviously a larger roational mass with the 35s which throws the speedo off a bit. The Rotational mass I wanna say varies 30 - 50 turns per mile from 33s to 35s.